T2 Subfields and Hormones Correlations with Subject 438
Shuying Yu and Caitlin Taylor
08/24/2022
Overview
This report provides exploratory and preliminary correlation analyses between sex hormones and T2 unretouched, raw hippocampal subfield data from the Healthy Aging Study sample (subjects 333 - 437, with 438 appended).
Black diamond point are the group means. Highlighted in purple triangle point and purple line is subject 438. Note that subject 438 was on estrogen HRT at the time of her scan and blood draw.
Cleaning data steps included:
- Filter participants that have T2 subfield data from scan
- Select sex hormone measures from when scan was conducted
- Correct left and right volumes with TIV
- Average left and right volumes to get an average measure for each subfield region
Sample size:
- Men = 24
- Women = 63 (24 pre, 20 peri, 19 post)
T2 Subfield Volume
CA1
Subject 438: average volume of 0.545094
Structural Comparison
Hormone Correlation by Reproductive Status
Hormone Correlation by Sex
CA2/3
Subject 438: average volume of 0.2098802
Structural Comparison
Hormone Correlation by Reproductive Status
Hormone Correlation by Sex
DG
Subject 438: average volume of 0.6703311
Structural Comparison
Hormone Correlation by Reproductive Status
Hormone Correlation by Sex
ERC
Subject 438: average volume of 0.4225437
Structural Comparison
Hormone Correlation by Reproductive Status
Hormone Correlation by Sex
PHC
Subject 438: average volume of 1.432311
Structural Comparison
Hormone Correlation by Reproductive Status
Hormone Correlation by Sex
PRC
Subject 438: average volume of 1.574246
Structural Comparison
Hormone Correlation by Reproductive Status
Hormone Correlation by Sex
SUB
Subject 438: average volume of 0.3014333
Structural Comparison
Hormone Correlation by Reproductive Status
Hormone Correlation by Sex
Summary
Subregion volumes for women and men were generally normally distributed. There appears to be two women whose SUB volumes appear to be outliers.
No significant trends seen in Pearson correlations for CA1, CA23, DG volumes.
No significant trends seen in Pearson correlations for estradiol, testosterone, or DHEAS.
No significant trends seen in Pearson correlations for men.
For progesterone, it was significantly positively correlated with ERC volume for post-menopausal women (p = 0.013) and significantly negatively correlated with ERC volume for pre-menopausal women (p = 0.035). However, the overall correlation between progesterone and ERC volume among women altogether was not significant. Progesterone was also marginally, positively correlated with PHC volume in women (p = 0.052), but could just be an effect of the outlier where a peri-menopausal woman has a very highe progesterone level (driving the overall trend and significance among peris, p = 0.036).
For FSH, it was significantly negatively correlated with PHC volume for pre-menopausal women (p = 0.04), but the overall correlation between FSH and PHC olume for women was not significant.
For SHBG, it was significantly negatively correlated with PRC volume for pre-menopausal women (p = 0.045) and marginally negatively correlated with women overall (p = 0.068). SHBG was also marginally negatively correlated with SUB volume for post-menopausal women (p = 0.068).